[0249] Metabolic Stability in SIF and SGF (Simulated Intestinal and Gastric Fluid) Assay Conditions [Drug] = 5 Buffer 1 = SGF without enzyme Buffer 2 = SGF with 0.32% pepsin Buffer 3 = SIF without enzyme Buffer 4 = SIF with 1% pancreatin Time = 0, 60, 120, and 240 min Temperature = 37C Experimental Protocol SIF was prepared freshly with 8.7 mM NaOH, 28.65 mM NaH2P04, 105.85 mM NaCl, with a final pH of 6.8
1 2 European Journal of Gastroenterology & Hepatology
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However, you may need to wait several weeks between stopping one medication and starting another to allow time for the first drug to exit the body fully and reduce the risks of side effects
