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In awake animals, glucose utilization either increased (Yudkoff et al., 2005), did not change (Al-Mudallal et al., 1995) or decreased (Mel et al., 2006), while brain glucose levels either increased (Mel et al., 2006), did not change (DeVivo et al., 1978

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doi: 10.1186/s13104-020-05427-1 120 LeiHSchmidt-BleekKDieneltAReinkePVolkHD

(2014) demonstrated that deleting the p66Shc gene, a key regulator of mitochondrial ROS production, reduced anxiety behaviors by reducing OS