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However, the eNOS activity can be lost or even the enzyme can be uncoupled by oxidative stress (Daiber et al., Despite the fact that ROS are being generated at injured and inflamed sites, it has been shown that low levels of ROS have an important regulatory role as signaling intermediates that are essential for different cell activities such as cell adaptation and growth (Abid et al., Background and Physiological Relevance ROS and Reactive Nitrogen Species ROS are molecules with unpaired electrons in their outer orbit

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Further research indicated that VNS mitigates ferroptosis in cardiomyocytes due to hepatic I/R by enhancing the SLC7A11/GPX4 axis, a crucial defense mechanism against ferroptosis

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