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Various potential ChaC1 modulators have been reported, targeting tumor cell cycle arrest and apoptosis (68,158)

doi:10.1111/jhn.12435 Akanchise T, Angelova A

doi: 10.1111/ceo.13818 135

This observation is consistent with their largely distinct sets of reported substrates and rationalizes the inability of PYK2 expression to rescue the phenotypes of FAK-null cells, although their distinct non-catalytic domains may also contribute to these differences 28,29