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During the training, the animals were randomly assigned to one of the four quadrants of the pool (northeast, northwest, southeast, and southwest) and tasked with locating a platform submerged 1 cm below the water surface in the northeast quadrant within 60 s

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Functional assessments such as creatine loading tests and advanced tissue imaging (e.g., magnetic resonance spectroscopy) may offer dynamic, patient-specific evaluations of mitochondrial responsiveness and guide individualized preventive protocols

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