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Furthermore, some disturbance in these organelles activates signaling pathways that alter cardiac ion channels function or expression, involved in the generation of an action potential that promotes arrhythmogenesis (Tse et al., 2016)

Toxic effects of lead exposure in Wistar rats: involvement of oxidative stress and the beneficial role of edible jute ( Corchorus olitorius ) leaves

Early hearing loss upon disruption of Slc4a10 in C57BL/6 Mice

However, glucose and/or adenosine triphosphate (ATP) deprivation, oxidative stress and compromised mitochondrial function may result in the accumulation of cytotoxic mediators and energy depletion