The CoQ10, a safe natural antioxidant, is supported by the lack of adverse effects
NO is generated by three different isoforms of the enzyme nitric oxide synthase (NOS), namely, inducible iNOS, endothelial eNOS, and neuronal nNOS
CRPC-reactive protein, CATcatalase, MPOmyeloperoxidase, FOXferroxidase, IMAischemia modified albumin, PON-1paraoxonase 1, TOStotal oxidant status, TAStotal antioxidant status, MDAmalondialdehyde, 8H2D8-hydroxy 2-deoxyguanosine, AOPPadvanced oxidation protein products, NADPH oxidasenicotinamide adenine dinucleotide phosphate, ROSreactive oxygen species, GSH-Pxglutathione peroxidase, GSHglutathione, TrxRthioredoxin reductase, FRAPferric reducing ability of plasma, ASarylesterase, OSIoxidative stress index, Pxsalivary peroxidase, SODsuperoxide dismutase, AGEadvanced glycation end-products, LOOHlipid hydroperoxides, OxLDLoxidized low-density lipoproteins, NOnitric oxide, 8-OHdG8-hydroxy guanosine, iNOSinducible nitric oxide, GSH-Rglutathione reductase, MSmetabolic syndrome, 25-OH-vitD25-hydroxy-vitamin D, ADAadenosine deaminase, s-TICserum trypsin inhibitory capacity, TBAthiobarbituric acid, ADatopic dermatitis, TPXtotal peroxide concentration, PCCprotein carbonyl compounds, PPpyrrolized protein, GSSGoxidized glutathione, HOhemoxygenase, TBtotal bilirubin, DBdirect bilirubin, IBindirect bilirubin, Cucopper, Feiron, Trftransferrin, Cpceruloplasmin, AuAb-oxLDLautoantibodies anti-oxidized LDL, SHthiol, SSdisulfide, CADcoronary artery disease, IL-6interleukin-6, Ab anti-CELanti-carboxyethyllysine antibodies, Ab anti CMLanti-carbocymethyllysine antibodies
[0385] The anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below
