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Description

Although most intracellular iron is tightly bound to proteins or incorporated into proteins as a cofactor or for storage, some free iron resides in the cytoplasm and intracellular organelles (such as lysosomes), constituting redox-active-dependent iron pools that regulate programmed cell death, including ferroptosis (Dixon and Stockwell, 2014)

NO-superoxide interaction can produce peroxynitrite an oxidative molecule that can cause lipid peroxidation, direct DNA damage and protein dysfunction (Radi et al., 1991a,b

Mini GK

En concentraciones lipolticas, la PPC se intercala en las bicapas lipdicas de los adipocitos e interrumpe la integridad de la membrana, desencadenando una lisis adipocitaria controlada: la interrupcin y eliminacin real de las clulas grasas en las reas tratadas