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Within hours after cleaning, teeth become coated with a layer of salivary proteins, which can isolate antibacterial materials from bacteria, thereby reducing antimicrobial efficiency and long-term efficacy ( In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials ( in vitro

Protein oxidation by H 2 O 2 can lead to allosteric changes that alter binding affinity for substrates or promote or inhibit enzymatic function [48,49,50,51]

Publishedonline March 23, 2020

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