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Consensus statement on management of intersex disorders

8 Molecular targets and signaling pathways While Section 6 outlined the broad systemic mechanisms, this section focuses on the specific molecular targets regulated by apigenin and ellagic acid

Across polyphenol subclasses, a recurring mechanistic theme is the concurrent suppression of NF-B-mediated inflammatory signaling and activation of the PI3K/Akt/GSK-3 pathway, which together reduce muscle catabolism, improve glycogen metabolism, and maintain mitochondrial membrane integrity during exercise