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Several techniques have been developed for the evaluation of the BBB such as the in vivo brain uptake index (BUI) method (88), in situ brain perfusion (89), cerebral microdialysis technique (90, 91), and cell uptake studies in the in vitro models of the BBB (92)

doi:10.1038/ncb1807, PMID: 19029908 Kizhakkayil J, Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S (2012) Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells