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Therefore, targeted suppression of the USP11-Nrf2 axis or promotion of Nrf2 ubiquitination to reduce the high expression of Nrf2 may represent effective strategies to reduce drug resistance and increase the susceptibility to ferroptosis of LUAD cells

Kragh et al., 2009)

3.1.4 Temozolomide Temozolomide (TMZ) is a common chemotherapeutic drug that is used to treat oncological diseases, such as breast and bladder cancers