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At the end of the recovery period, nasal carcinomas were observed in 1/26 males and 1/27 females versus 0/24 and 0/23 in controls, and the incidence of laryngeal carcinomas was increased (5/23 in males, 3/20 in females, against 0/20 and 0/22 in controls)

Cartilage has limited circulation and lacks direct nerve connections, so nutrients and repair signals move slowly

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While substantial advances have shaped our understanding of ferroptosis 1 , GPX4-restricted immunologic responses remain poorly explored despite reports of inflammatory tissue injury in GPX4-deficient animals 9,11,27