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Most studies indicate elevated levels of CSF IGF-2 in patients with AD [123, 139, 142, 143], positively correlated with CSF A 1-42 and p-Tau levels [143]

Soriano GP, Besse L, Li N, Kraus M, Besse A, Meeuwenoord N, Bader J, Everts B, den Dulk H, Overkleeft HS, et al

Essentially, this methodology seeks linear combinations of z500 or SST that can be used to generate a predictor time series that explains the maximum amount of variance in TX10d or TX90d unaccounted by the original three predictors

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