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The four most common oral hypoglycemics, sulfonylureas/insulinotropics, biguanides, -glucosidase inhibitors, and thiazolidinediones, have demonstrated efficacy but also safety concerns (35)

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

Elevated polyamine levels are necessary for neoplastic transformation and tumor progression (Casero et al., Arginine and arginine-dependent polyamine production are important not only for biomass synthesis, which supports tumor aggressiveness, but also as regulators in immunometabolism (Mondanelli et al., 2017), which represents an important target for effective cancer immunotherapy