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Insights into battles between Mycobacterium tuberculosis and macrophages

A mild deficiency may have no symptoms, but a more severe or prolonged deficiency can exhibit the following: Microcytic anemia Skin conditions Depression Confusion Lowered immunity Certain conditions can increase the risk of developing a deficiency by interfering with the absorption of vitamin B6: Kidney disease Autoimmune intestinal disorders like celiac disease, ulcerative colitis, and Crohns disease Autoimmune inflammatory disorders such as rheumatoid arthritis Alcoholism Toxicity It is quite unlikely to reach a toxic level of vitamin B6 from food sources alone

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Thus, immune responses to life saving therapeutics such as Enzyme Replacement Therapies (ERT) for Lysosomal Storage Diseases and Factor VIII for Hemophilia A constitute a severe risk necessitating mitigating strategies