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Additionally, a B-complex supplement providing 1,000 mcg of B-12 daily was found to increase the risk of heart attack, stroke and death in people with type 1 or type 2 diabetes who had advanced kidney disease (Cappello, Nutrients 2017)

MicroRNA-17-5p Reduces Inflammation and Bone Erosions in Mice With Collagen-Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

What makes MOTS-c particularly interesting for osteoporosis research is that it appears to affect both sides of the bone remodeling equation, promoting bone formation while simultaneously inhibiting bone breakdown