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The copper ionophore elesclomol triggers Cuproptosis in cancer cells, which is linked to ferrodoxin-1 (FDX1) levels, elevated mitochondrial respiration rate, and copper availability [168, 169]

Mutation of the strictly conserved guiding bar residue Asn419 hTrxR1 alone led to a strong effect (Table 2), rendering it the most important residue for aligning the flexible C-terminal arm during catalysis

These are differentiated melanocytes that migrate downwards into the hair bulb to regenerate pigmented hair [180]

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