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The interrelationship among radiotherapy, chemotherapy, anti-tumor immunity, and hypoxia-inducible factors-1 (HIF-1)

Examination of oxidative stress The effect of APE on oxidative stress in LPS-stimulated RAW264.7 cells were assessed by measuring malondialdehyde (MDA) levels via the thiobarbituric acid reactive substances (TBARS) assay, and by evaluation of intracellular glutathione status (GSH and GSSG levels)

These associations may indicate immune dysregulation rather than direct viral oncogenesis, yet they remain clinically relevant as potential indicators of elevated risk

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