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doi:10.3810/pgm.2010.03.2128 29

Intracellular challenges The delivery of siRNA into target cells is a complex process that involves overcoming several intracellular barriers, including cell membrane permeability, endosomal escape, degradation by nucleases, and intracellular trafficking (Fig

SPSS 20.0 software package was used for statistical analysis, and lifetime table method was used to calculate the cumulative progression rate and the annual incidence of end-point events (cirrhosis, liver cancer, death)