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In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

These effects are attributed to its action on the NO system, enabling vascular tone adjustment according to physiological conditions

BPC-157 is studied for angiogenic and growth-factor signalling activity, including effects on the VEGF/VEGFR2 and FAK-paxillin pathways

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