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doi:10.3389/fcvm.2024.1288659 Akkus NI, Abdulbaki A, Jimenez E, Tandon N

In 2007, a clinical trial on 25 patients with advanced CRC documented the safety and well-tolerability of combining angiogenesis inhibitor vatalanib, an inhibitor of VEGFR tyrosine kinases, with oxaliplatin/5-FU/leucovorin (FOLFOX4) chemotherapy [154]