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The ideal neuroprotection strategy would be to prevent BCB breakdown and stabilize it, thereby protecting the brain from factors released from damaged blood vessels that cause further damage

The literature survey reveals that a few stability indicating RP-HPLC methods for NAC are available [47]Ercal N, Oztezcan S, Hammond TC, Matthews RH, Spitz DR

Conjugated bilirubin (mostly as the diglucuronide form) is then secreted into the biliary canaliculus via a complex carrier-mediated mechanism

This means that an oral bioavailability of 1% can suffice as a top-up once steady state plasma levels are achieved in 4-5 weeks