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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis

This combination of modelling and cost-effectiveness principles aligns with common practice in the health economic literature and in philanthropic decision-making

10.1038/s41467-021-27640-7 181 QinX.LuY.BianM.XiaoZ.ZhangY.YuanY

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