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Glutamine anaplerosis supplies glutamate, while the transsulfuration pathway provides cysteinethe rate-limiting precursor for GSH biosynthesis [57, 97]

KD appears well positioned to intervene in this process, overlapping with broader microbiota-targeted strategiesincluding probiotics, synbiotics, FMT, and antibioticsthat are increasingly regarded as potential disease-modifying interventions in PD [129, 177]

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By supporting healthy inflammatory responses, NAC helps ensure that the immune system can respond appropriately to challenges while avoiding the negative effects of chronic inflammation