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However, hyperinsulinemia can reduce glycogenolysis in the liver, leading to reduced production of glucose and decreased levels in peripheral blood (transient hypoglycemia), which promotes fasting metabolism [249]

This accumulation leads to rampant oxidative stress, mitochondrial damage, and systemic inflammation

A recent paper using the zebrafish tailfin regeneration model demonstrated that Sonic hedgehog (Shh) a key signalling protein in the hedgehog signalling cascade acted downstream of NOX to increase SOD activity and H 2 O 2 production in the early stage of tailfin regeneration, most likely due to SOD oxidation 130

BDNF can positively regulate miR-124 but not miR-132 [70]