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Based on the findings of the present study that the risk of ESRD imposed by RA is relatively higher in relatively young and healthy individuals, administration of biologic agents in this specific population should be preferentially considered among these patients with RA

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Liquid chromatography-mass spectrometry-based assays for acetyl-CoA (and other CoA derivatives) have been developed, validated, and applied in different contexts, with liquid chromatography-tandem mass spectrometry (LC-MS/MS), liquid chromatography-high resolution mass spectrometry (LC-HRMS), direct injection HRMS, and capillary electrophoresis-MS methods reported [3-13]