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Notably, the algorithms that we propose here are similar to the approach used in the recent BATCH study in which a PCT-guided algorithm for antibiotic duration was non-inferior to usual care without PCT among all patients, but did safely reduce the median antibiotic duration in the subset with adherence to the PCT-guided algorithms

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NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs

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