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Description

It also helps in reversing the imbalance of matrix metalloproteinases (MMP-9) and their inhibitors (TIMP-1), and in preventing epithelial-mesenchymal transition (EMT) through the modulation of Nrf2, NF-B, and TGF-1/Smad2/3 signaling pathways 6

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Aged mice were intraperitoneally injected with 5 mg/kg FOXO4-DRI or PBS as a control every other day for three administrations, and effects were assessed 30 days post-treatment