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Another in vivo imaging study reports that brain capillary endothelial cells control blood flow through a hierarchy (Longden et al., 2021) of inositol 1,4,5-triphosphate receptor, type 3 (IPTR3)-mediated Ca 2+ events, ranging from small, sub-second proto-events, demonstrating Ca 2+ release through a small number of channels, to high amplitude, sustained (up to ~1 min) compound events mediated by large clusters of channels (Longden et al., 2021

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Kokkinopoulos I, Jordan WJ, Ritter MA

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles