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In addition to maintaining hepatic metabolic homeostasis, AMPK activation has been reported to promote mitochondrial function and suppress endoplasmic reticulum (ER) stress 22

[205] [198] [76] Phosphorylation of DAT by either kinase induces transporter internalization (non-competitive reuptake inhibition), but PKC-mediated phosphorylation alone induces the reversal of dopamine transport through DAT (i.e., dopamine efflux)

Additionally, PD pathogenesis primarily involves vesicular transport and the maintenance of lysosomes and mitochondria [50]

Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure