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This depletion can manifest itself in ways that might include impaired nutrient absorption and assimilation, gut, lung, eye, blood, skin, and brain issues, keloid scarring, mitochondrial stress for lower energy output, DNA mutation, mass oxidation, and free radical overload

Abbreviations ALT: Alanine transaminase AST: Aspartate transaminase AKT/mTOR: Protein kinase B (also known as AKT)/mechanistic target of rapamycin hTERT-HSC: Immortal activated human hepatic stellate cells IL: Interleukin JAK/STAT: Janus kinasesignal transducer and activator of transcriptions JNK pathways: c-Jun N-terminal kinase (a type of MAPK pathway) MAPK/ERK: Mitogen-activated protein kinase/extracellular signal-regulated kinase MTX: Methotrexate MTX-PGs: Methotrexate-polyglutamate STAT3: Signal transducer and activator of transcription 3 TGF-1: Transforming growth factor receptor beta-1 TLRs: Toll like receptors TNF-: Tissue necrosis factors-alpha TWEAK Pathways: TNF-like weak inducer of apoptosis References Komiski P, Halik PK, Chesori R, Gniazdowska E (2020) Overview of dual-acting drug methotrexate in different neurological diseases, autoimmune pathologies and cancers

DR is a leading cause of global vision loss