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Given their ineffectiveness as a monotherapy, they have been utilized in combination therapies and are typically administered concurrently with hydroxychloroquine or amantadine, which raises vacuolar pH

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The following clinically significant adverse reactions are described elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice