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While our study demonstrates that irisin exerts neuroprotective effects on dopaminergic neurons in an MPTP-induced Parkinsons disease mouse model, it is important to consider potential off-target effects associated with systemic administration

These varying results are likely attributed to interactions between energy and protein intake, as well as the supplementation of essential amino acids and the balance among amino acids

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Yoshizawa-Fujita, M., Tamura, T., Takeoka, Y