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10.1089/dna.2015.3118 183 WilliamsF

Evidence shows that in addition to interhemispheric EEG asymmetry, insomnia had greater fronto-parietal asymmetry in the left hemisphere, particularly in slow frequency bands (delta and theta) during the REM sleep, when compared to the healthy controls 41

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

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