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In this study, a PCPA-induced insomnia model in rats was used to successfully simulate the pathological process of insomnia induced by neurotransmitter disorders, psychological stress, and environmental factors by activating the hypothalamicpituitaryadrenal (HPA) axis and inhibiting the synthesis of 5-HT, providing a reliable model basis for exploring the complex mechanism of insomnia and its drug intervention

They offer critical guidance on suitable dosages, potential interactions with medications, and the importance of ongoing monitoring

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& Vecsei, L