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Patients with malabsorption syndromes or post-bariatric surgery

Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

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This matters for dosing because beta-3 receptor sensitivity varies throughout the day and in response to nutritional status