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This leads to a decrease in migration and proliferation of cancer cells and sensitizes them into OX chemotherapy (Yin et al., 2019)

A rat study found that EGCG exerted direct NOS-dependent vasodilatory effects in skeletal muscle, without immediate changes in muscle glucose uptake or amplification of insulins vascular and metabolic effects in healthy rats (Ng et al., 2017)

Thus, vitamin C is an important antioxidant against reactive oxygen and nitrogen species that are naturally produced during cell metabolism (Przybylo and Langner, 2020

Based on this mechanistic insight, we hypothesized that co-targeting both pathways would overcome resistance