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doi: 10.3390/GENES12060852 82 SharpRCBrownMEShapiroMRPosgaiALBruskoTM

Furthermore, tPA intervention increased brain matrix metalloproteinase (MMP-9) (Yang et al., 2016), as well as phosphorylation of connexin43, a gap junction protein contributing to blood brain barrier permeability and hemorrhagic transformation (Tang and Han, 2013)