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Similarly, in patients with hypertension and hyperhomocysteinemia (18 males and 7 females, age 4065), reactive hyperemia is improved by 4 weeks oral L-arginine (Reule et al., 2017), administered in a mixture with pycnogenol, which itself activates eNOS (Fitzpatrick et al., 1998)

doi:10.1007/s00125-021-05557-6 4

Second, some clinical studies have potential limitations due to the limited number of cancer patients participating in the study and the lack of long-term follow-up of measured outcomes