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For compounds targeting the brain, this additional quality assurance is worth the investment

Nat Neurosci 13:12161224 Jocoy EL, Andre VM, Cummings DM, Rao SP, Wu N, Ramsey AJ, Caron MG, Cepeda C, Levine MS (2011) Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum

However, it also underscores the critical importance of ethical considerations, especially when dealing with powerful compounds not yet approved for therapeutic use

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