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Overall, clearance of MHD is split ~50/50 between hepatic and renal clearance

This process not only lightens pigmentation but also supports overall skin health by protecting cells from oxidative damage

The study was double-blind, placebo-controlled and involved 66 subjects randomly divided into 3 groups: placebo, arginine-supplementation, and beetroot extract-supplementation groups

For example, in individuals with a 46,XY karyotype and 5-reductase deficiency or 17-hydroxysteroid dehydrogenase deficiency diagnosed at birth, current guidelines support assigning sex in accordance with chromosomal and gonadal sex, as is also recommended for individuals with 46,XX CAH