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& Jacob, S

Over time, these processes have led to the emergence of many superbugs. For example, surveillance data show that 42% of Escherichia coli isolates worldwide are resistant to third-generation cephalosporins and 15% of Staphylococcus aureus isolates are methicillin-resistant (MRSA) in elderly individuals

Finally, in vitro work has looked at cellular signaling downstream of 3-AR engagement, providing mechanistic support for the lipolysis-without-hyperglycemia profile that investigators consistently observe

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