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Nakamura H, Kawakami A

Retinal sections were immunolabeled with anti-RBPMS antibody and an antibody against pimonidazole (Pimo) that was conjugated to Pacific Blue fluorophore, then cover-slipped with Fluoromout G (Southern Biotech) for imaging

FIGURE 4 The previously documented constituents demonstrate multi-target efficacy against VEGF-driven tumor angiogenesis: fucoidan exhibits pan-inhibitory efficacy across diverse malignancies, including multiple myeloma (RPMI-8226, U266) and breast cancer (4T1), which suppresses VEGF expression to potently ameliorate tumor neoangiogenesis (Xue et al., 2012

These findings highlight the systemic, multi-faceted nature of oxidative stress in chronic illness and reinforce the critical need for broad-spectrum antioxidant support like glutathione to protect cellular architecture across diverse patient populations