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As some studies point out that chronic exposure to nicotine may impair the sensitivity of nAChRs (Buisson and Bertrand, 2001), the long-tern effect of nicotine is questionable and should be verified in the future

At 414.605, ALS2 is defined as either transportation by ground ambulance vehicle, medically necessary supplies and services, and the administration of at least three medications by intravenous push/bolus or by continuous infusion, excluding crystalloid, hypotonic, isotonic, and hypertonic solutions (Dextrose, Normal Saline, Ringer's Lactate)