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In addition to the ongoing clinical trials for the DNA targeting of SLC7A11, two anti-xCT vaccines are in the preclinical testing phase, at the time of writing (44,96,97)

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

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However, a recent preprint study indicated that endothelial ALOX15 might have a protective effect in mild lung thrombosis during sepsis-induced ALI [67], suggesting the possible multiple roles of ALOX15 in sepsis-induced ALI