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54 Diabetic macroangiopathy and microangiopathy mutually promote each other, and the occlusion of macrovessels can cause chronic perfusion insufficiency in the brain and microvascular disorders

The Lancet Neurology In the LEGATO-HD Phase 2 double-blind, placebo-controlled trial of laquinimod in patients with HD, laquinimod did not show a significant effect on motor symptoms assessed by the UHDRS-TMS but significantly reduced caudate volume loss compared with placebo at week 52

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