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Other factors that trigger pyocyanin-mediated oxidative stress in airway epithelial cells include inhibition of catalase activity and depletion of NADPH ( Oxidative stress mediated by pyocyanin has a strong inhibitory effect on A549 cell multiplication (growth) and confluence

Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast BJ, Reardon C, Shaw AC, Sengupta S, Szentirmai , Thakkar M, Walker WE, Solt LA (2020) Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary