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To test if this mechanism was at play upon depleting GSH in the liver, we treated Gclc L-KO mice with T0901317, an LXR agonist

Molecular Profile Peptide: AOD-9604 Type: GH fragment (176191) analogue Sequence Length: 15 amino acids Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Phe-Tyr-Ser-OH Molecular Weight: ~ 1,813 Da Form: Lyophilized powder Purity: 98% (HPLC tested) Storage & Stability Store lyophilized peptide at 20C Protect from heat, moisture, and light Reconstituted solutions should be used promptly or stored per laboratory protocol Avoid repeated freeze-thaw cycles What the Research Shows About AOD-9604 & Cartilage 1

Yeom SK, Lee CH, Cha SH, Park CM

(See also Table 1)