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GPX4 inhibition activated ferroptosis, inducing TC cell death, rapid rise in reactive oxygen species and effectively arrested cell migration in vitro

6), which was consistent with the results shown in Fig

Although inflammatory biomarkers such as c-reactive protein (CRP), tumor necrosis factor alpha (TNF) and interleukin-6 (IL6) are elevated in serum of cirrhosis patients and associated with worse outcomes, these markers are not routinely checked due to the invasive nature of blood draws and difficulty in interpretation of a single measurement

9 Besides regulating macrophage polarization, NRF2 can also directly block the transcription of pro-inflammatory cytokines, thereby inhibiting the inflammatory response of macrophages